To the Editor: We would view with caution the conclusion ofHerrington and colleagues (Aug. 24 issue)1 that women with establishedcoronary heart disease should not use estrogen replacement withan expectation of a cardiovascular benefit. The results of theirstudy apply only to the use of conjugated equine estrogens ata dose of 0.625 mg daily, alone or in combination with medroxyprogesteroneacetate. Their findings may not be relevant to other estrogensand progestogens used in hormone-replacement therapy.
The effects of estrogens on the risk of cardiovascular diseasevary according to the type of estrogen, the dose, and the . . . [Full Text of this Article]
References
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