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Figure 1. A 77-year-old woman with cirrhosis was admitted with a one-week history of altered sensorium. A prior evaluation of her liver disease disclosed only a serum alpha1-antitrypsin level of 30 mg per deciliter (reference range, 93 to 224). The patient had no evidence of pulmonary disease. Eventually, she died of liver failure and complications of gram-negative sepsis. At autopsy the liver weighed 725 g (reference range, 1500 to 1800) and had extensive micronodular cirrhosis (Panel A). Trichrome staining of histologic sections demonstrated prominent fibrosis (blue staining in Panel B, x100). Multiple diastase-resistant periodic acid–Schiff–positive cytoplasmic eosinophilic . . . [Full Text of this Article] |
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