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Previous Volume 343:1969-1971 December 28, 2000 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In his otherwise excellent review (July 27 issue),¹ Dr. Barnes did not adequately address the role of bacterial infection in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD). Four studies have demonstrated the presence of substantial concentrations of potential respiratory bacterial pathogens in distal airway secretions in samples obtained through a bronchoscope in approximately half of all patients during an acute exacerbation.² Immunologic studies using homologous strains and immunoassays specific for surface-exposed epitopes have demonstrated the development of specific antibodies to bacterial pathogens that were isolated during an acute exacerbation.² We have recently demonstrated . . . [Full Text of this Article]

References

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