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Previous Volume 343:1972-1973 December 28, 2000 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The report by Harris and Douglas (Aug. 17 issue)¹ on the enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute is predicated on the assumption that the proportions of men and women represented in trials should mirror some underlying ideal — in the authors' case, the difference in the prevalence of cardiovascular disease among men and women in the general population. Using that construct, they examined classes of trials in which women were "underenrolled" (most notably, trials involving heart failure). But then why not characterize women as having been "overenrolled" . . . [Full Text of this Article]

References

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• Ding, E. L., Powe, N. R., Manson, J. E., Sherber, N. S., Braunstein, J. B. (2007). Sex Differences in Perceived Risks, Distrust, and Willingness to Participate in Clinical Trials: A Randomized Study of Cardiovascular Prevention Trials. Arch Intern Med 167: 905-912 [Abstract] [Full Text]  
• Murthy, V. H., Krumholz, H. M., Gross, C. P. (2004). Participation in Cancer Clinical Trials: Race-, Sex-, and Age-Based Disparities. JAMA 291: 2720-2726 [Abstract] [Full Text]