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Previous Volume 343:1973-1974 December 28, 2000 Number 26 Next

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To the Editor: Rapid pharmacologic control of severe hiccups is a difficult problem.¹ The preferred drugs for treating hiccups are dopaminergic blockers or antagonists. Nefopam (3,4,5,6-tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride) is a centrally acting nonopioid analgesic agent with antishivering effects² that is structurally related to antihistamines and antiparkinsonian drugs.³ We report the use of intravenous nefopam in three patients with incapacitating hiccups.

A 32-year-old woman with lymphoblastic leukemia was hospitalized because she had had intense, nearly continuous hiccups for 48 hours. Vagal maneuvers, chlorpromazine (10 mg intravenously three times a day for 24 hours), and lidocaine (a loading dose of 1 . . . [Full Text of this Article]

References

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Pötzsch B., Klövekorn W.-P., Madlener K.
Extract | Full Text  
N Engl J Med 2000; 343:515, Aug 17, 2000. Correspondence

This article has been cited by other articles:

• Pajot, S., Geeraerts, T., Leblanc, P.-E., Duranteau, J., Benhamou, D. (2007). Hiccup during weaning from mechanical ventilation: the use of nefopam. Br J Anaesth 99: 748-749 [Full Text]