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Previous Volume 343:1975 December 28, 2000 Number 26 Next

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Third edition. Edited by Meir H. Kryger, Thomas Roth, and William C. Dement. 1336 pp., illustrated. Philadelphia, W.B. Saunders, 2000. $145. ISBN 0-7216-7670-7.

Principles and Practice of Sleep Medicine encompasses the pathophysiology, diagnosis, and treatment of disorders resulting from disruptions of the sleep–wake cycle and circadian rhythm. This is a relatively new area for medical practice. Some 50 years ago, rapid-eye-movement (REM) sleep was discovered by Eugene Aserinsky and Nathaniel Kleitman at the University of Chicago, and 25 years ago the first clinical center for sleep disorders in the United States was established in the department of psychiatry at Stanford University. Now, the obstructive sleep apnea syndrome, the restless-legs syndrome, and narcolepsy are recognized as common diseases requiring clinical resources and attention. . . . [Full Text of this Article]

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