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Previous Volume 343:185-189 July 20, 2000 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hemangiomas are the most common tumors of infancy, with a prevalence of 5 to 10 percent among one-year-olds. They are characterized by rapid growth in the first year of life, followed by involution and gradual regression by adolescence.^1,2 We recently treated a three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion. This finding suggested that the rate of degradation of thyroid hormone was accelerated. We subsequently identified high levels of type 3 iodothyronine deiodinase activity in the hemangioma tissue. This selenoenzyme, normally present in the . . . [Full Text of this Article]

Case Report

Methods

Tissue Preparation

Type 3 Iodothyronine Deiodinase Assays

Northern Blot Analysis

In Situ Hybridization

Retrospective Review of Patients with Hemangioma

Results

Analysis of Type 3 Iodothyronine Deiodinase Activity in Hemangioma Tissue from the Patient

Retrospective Review of Patients and Analysis of Type 3 Iodothyronine Deiodinase Activity in Hemangioma Tissue from Other Patients

Discussion

Source Information

From the Division of Endocrinology (S.A.H., M.V., A.J.B.), the Departments of Pathology and Pediatrics (H.P.W.K.), and the Department of Surgery and the Vascular Anomalies Center (S.J.F.), Children's Hospital; and the Thyroid Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (H.M.T., J.W.H., P.R.L.) — all in Boston.

Address reprint requests to Dr. Larsen at the Thyroid Division, Harvard Medical School, Rm. 560, Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, Boston, MA 02115, or at larsen@rascal.med. harvard.edu.

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