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Figure 1. A 45-year-old man with a 70-pack-year history of smoking began to have pain and then swelling in his right foot and ankle. He had no history of trauma. The radiographic findings were inconclusive, and the chest film was normal. Magnetic resonance imaging of the foot showed a large enhancing lesion of the calcaneus (arrow in Panel A). A bone scan (Panel B) showed abnormalities in the right calcaneus and the right humerus consistent with the presence of a metastatic tumor. A needle biopsy of the calcaneus lesion showed moderately differentiated adenocarcinoma; the results of immunohistochemical staining were . . . [Full Text of this Article] |