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Correspondence
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Volume 343:365-366 August 3, 2000 Number 5
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Liver Damage Due to Alendronate

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To the Editor: Alendronate is indicated for the treatment of postmenopausal women with osteoporosis and patients with glucocorticoid-induced osteoporosis.1 We report liver dysfunction due to alendronate in a postmenopausal woman given the drug for osteoporosis.

A 71-year-old woman was referred to our clinic for an evaluation of osteoporosis. She had been thought to have primary biliary cirrhosis four years earlier, was receiving ursodeoxycholic acid (ursodiol), and had normal liver function. The diagnosis of primary biliary cirrhosis had been based on high serum alkaline phosphatase and antimitochondrial antibody concentrations, but liver biopsy had not been performed.

Three years later, on evaluation . . . [Full Text of this Article]

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