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Previous Volume 343:371-372 August 3, 2000 Number 5 Next

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By Frances M. Ashcroft. 502 pp., illustrated. San Diego, Calif., Academic Press, 2000. $75. ISBN 0-1206-5310-9.

This book reviews a wide variety of congenital and acquired conditions caused by abnormalities in ion-transport mechanisms. It starts with a description of relatively simple channels that respond to voltage changes or certain cellular metabolites by a conformational change that opens the pore. These channels are closed by a cytosolic loop that plugs the pore. The book continues with more complex channels composed of multiple subunits of the same composition and controlled by other subunits with a different composition. The complexity increases in a last group of ion channels that regulate more than one type of ion passage and form . . . [Full Text of this Article]

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