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Previous Volume 343:411-419 August 10, 2000 Number 6 Next

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Almost a century ago, in 1901, Eugene L. Opie described "hyaline degeneration of the islands of Langerhans" in the pancreas of patients with hyperglycemia (Figure 1).¹ A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein. The chief component of the proteinaceous deposits described by Opie — later referred to as islet amyloid — was identified in 1986 as a protein of beta-cell origin named islet amyloid polypeptide.² Islet amyloid is a characteristic pathological finding in patients with type 2 diabetes mellitus, being present in more than . . . [Full Text of this Article]

Amyloid

Islet Amyloid and Type 2 Diabetes Mellitus

Islet Amyloid and Islet Amyloid Polypeptide

The Expression of Human Islet Amyloid Polypeptide in Transgenic Mice

Cytotoxicity of Human Islet Amyloid Polypeptide and Islet Amyloid

Islet Amyloid as a Target for Therapy in Type 2 Diabetes

Inhibition of the Production of Islet Amyloid Polypeptide

Direct Inhibition

Indirect Inhibition

Inhibition of the Formation of Amyloid Fibrils

Conclusions

Source Information

From the Departments of Internal Medicine (J.W.M.H., C.J.M.L.) and Pathology (J.W.M.H.), University Medical Center, Utrecht, the Netherlands; and the Department of Medicine, Lund University and Malmö University Hospital, Malmö, Sweden (B.A.).

Address reprint requests to Dr. Höppener at University Hospital Utrecht, H 04.312, P.O. Box 85500, 3508 GA Utrecht, the Netherlands, or at j.w.m.hoeppener@lab.azu.nl.

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