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Previous Volume 343:441-442 August 10, 2000 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Thyroid dysgenesis (thyroid aplasia or an ectopic thyroid gland) is responsible for 85 percent of cases of congenital hypothyroidism. The pathogenesis of thyroid dysgenesis is not known. Although a few familial cases have been reported,^1,2 the disorder is considered to be sporadic. Some cases caused by mutations of several genes involved in thyroid organogenesis (the thyroid transcription factor 1 and 2 genes and PAX 8) and the gene for the thyrotropin receptor have been reported.^3,4,5 However, among cases of congenital hypothyroidism, the proportion of familial cases caused by thyroid dysgenesis is not known.

In a study . . . [Full Text of this Article]

References

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