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Correspondence
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Volume 343:445-446 August 10, 2000 Number 6
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Fetal Effects of Metoclopramide Therapy for Nausea and Vomiting of Pregnancy

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To the Editor: Many pregnant women have nausea and vomiting during the first trimester; these effects may be severe and in some women they continue beyond the first trimester.1 The cause is likely to be multifactorial, and the disorder is a diagnosis of exclusion.2 Since the thalidomide tragedy, there is heightened awareness of the risks of drug therapy during pregnancy in general and of antiemetic therapy in particular.3 Although not licensed for nausea and vomiting of pregnancy, metoclopramide is the antiemetic drug of choice in pregnancy in several European countries.4 There have, however, been no prospective studies of the fetal . . . [Full Text of this Article]

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