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Previous Volume 343:577-578 August 24, 2000 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their study of the histochemical detection of metastases from breast cancer to bone marrow, Braun et al. (Feb. 24 issue)¹ found that multivariate analysis identified the presence of cytokeratin-positive cells in the bone marrow as an independent predictor of survival. What do the authors think about the use of flow cytometry after cytokeratin staining? Their results clearly demonstrate that the presence of cytokeratin-positive cells in the bone marrow of patients with breast carcinoma is associated with shorter survival. However, because cytokeratin-positive cells were detected in control patients with nonmalignant disease and stage I tumors had fewer . . . [Full Text of this Article]

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