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Correspondence
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Volume 343:584-585 August 24, 2000 Number 8
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Patients with Acute Chest Pain

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 by Lee, T. H.
To the Editor: In their review article on the evaluation of patients with acute chest pain, Lee and Goldman (April 20 issue)1 did not comment on the usefulness of measurements of serum myoglobin. Myoglobin, a relatively small protein (17.8 kd), appears in the peripheral blood much earlier during acute myocardial infarction than other cardiac markers such as creatine kinase MB and troponins. The diagnostic sensitivity of myoglobin levels for acute myocardial infarction ranges from 43 to 100 percent. The wide variability is in large part due to differences in the cutoff values used to define a positive test (ranging from . . . [Full Text of this Article]

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