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Previous Volume 344:30-37 January 4, 2001 Number 1 Next

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Allergic rhinitis, asthma, and atopic eczema are among the commonest causes of chronic ill health. These diseases are increasing in prevalence, and they add considerably to the burden of health care costs. In Sweden, for example, the number of children with allergic rhinitis, asthma, or eczema roughly doubled over a 12-year period,¹ and in the United States the annual cost of treating asthma is about $6 billion.²

The term "allergy" was introduced in 1906 by von Pirquet, who recognized that in both protective immunity and hypersensitivity reactions, antigens had induced changes in reactivity.³ With the passage of time the word . . . [Full Text of this Article]

Atopy and Type 2 Helper T Cells

Rising Incidence of Allergic Disease

Allergens

Genetics

IgE and Its Receptors

Allergic Inflammation

Source Information

From the Imperial College School of Medicine, National Heart and Lung Institute, London.

References

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• Maziak, W. (2009). The triumph of the null hypothesis: epidemiology in an age of change. Int J Epidemiol 38: 393-402 [Abstract] [Full Text]  
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