Misoprostol is a prostaglandin E1 analogue that has been approvedby the Food and Drug Administration (FDA) to be taken orallyfor the prevention and treatment of gastric ulcers associatedwith the use of nonsteroidal antiinflammatory drugs. It hasalso become an important drug in obstetrical and gynecologicpractice because of its uterotonic and cervical-ripening actions.Misoprostol is useful for elective medical abortion, cervicalripening before surgical abortion, evacuation of the uterusin cases of embryonic or fetal death, and induction of labor.The drug may also be used to treat and even prevent postpartumhemorrhage. However, misoprostol is not . . . [Full Text of this Article]
Pharmacokinetics, Physiology, and Teratogenicity
Misoprostol in the First Trimester of Pregnancy
Medical Abortion
Failed Pregnancy or Fetal Death
Cervical Ripening before Surgical Abortion
Misoprostol in the Second Trimester of Pregnancy
Abortion
Misoprostol in the Third Trimester of Pregnancy
Induction of Labor with a Viable Fetus
Induction of Labor after Fetal Death
Induction of Labor in Women with Previous Cesarean Delivery
Misoprostol for Postpartum Hemorrhage
Conclusions
Source Information
From the Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Health Research and Policy, San Francisco General Hospital and the University of California, San Francisco.
Address reprint requests to Dr. Goldberg at the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco General Hospital, 1001 Potrero Ave. Ward 6D-11, San Francisco, CA 94110.
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