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Correspondence
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Volume 344:69 January 4, 2001 Number 1
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Autologous Hematopoietic Stem-Cell Transplantation for Behçet's Disease with Pulmonary Involvement

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To the Editor: The prognosis for patients with Behçet's disease and pulmonary involvement is poor.1 Half the patients die within three years after the onset of hemoptysis.2 We describe the successful treatment of two patients with Behçet's disease and pulmonary bleeding with the use of high-dose chemotherapy and hematopoietic stem-cell transplantation. Both patients had disease that was refractory to conventional immunosuppressive therapy and had recurrence of disease activity after attempts to reduce the doses of oral cyclophosphamide and prednisone.

The first patient, a 32-year-old man, presented with recurrent aphthous ulcers, fever, polyarthritis, erythema nodosum, and an intracardiac thrombus. His disease . . . [Full Text of this Article]

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