To the Editor: The prognosis for patients with Behçet'sdisease and pulmonary involvement is poor.1 Half the patientsdie within three years after the onset of hemoptysis.2 We describethe successful treatment of two patients with Behçet'sdisease and pulmonary bleeding with the use of high-dose chemotherapyand hematopoietic stem-cell transplantation. Both patients haddisease that was refractory to conventional immunosuppressivetherapy and had recurrence of disease activity after attemptsto reduce the doses of oral cyclophosphamide and prednisone.
The first patient, a 32-year-old man, presented with recurrentaphthous ulcers, fever, polyarthritis, erythema nodosum, andan intracardiac thrombus. His disease . . . [Full Text of this Article]
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