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Editorial
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Volume 344:843-844 March 15, 2001 Number 11
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Breaching the Barrier of ABO Incompatibility in Heart Transplantation for Infants

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 by West, L. J.
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Cardiac transplantation has now been performed for 15 years as therapy for neonates and infants with lethal myopathic or structural heart disease. Such transplantation has been stimulated by both the needs of the infants and the promise of an immunologic window of opportunity for safe transplantation, owing to the immaturity of infants' immune systems. The first series of three infants with hypoplastic left heart syndrome who underwent orthotopic heart transplantation was reported by Bailey and colleagues in 1986.1 Subsequently, infants have accounted for approximately 40 percent of all heart transplantations in children. However, the number of such procedures in children, . . . [Full Text of this Article]

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