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Correspondence
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Volume 344:933-935 March 22, 2001 Number 12
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Folic Acid Antagonists during Pregnancy and Risk of Birth Defects

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To the Editor: Hernández-Díaz and colleagues (Nov. 30 issue)1 suggest that the use of folic acid antagonists in pregnant women increases the risk of oral clefts and cardiovascular and urinary tract defects in their infants. The possible role of trimethoprim in increasing the risk of malformations of the cardiovascular and urinary systems has practical implications. Trimethoprim is one of the most commonly prescribed drugs in the United States. Furthermore, it is commonly given in the early stages of pregnancy, often before women are aware that they are pregnant. In their report, Hernández-Díaz and colleagues group together data on trimethoprim, triamterene, . . . [Full Text of this Article]

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