Complement at the Interface between Innate and Adaptive Immunity
The formation of an antibody–antigen complex (immune complex)is the principal way of activating the classical pathway ofthe complement system. C1q, an integral part of the first componentof complement (C1), triggers the activation process when itdocks onto antibodies within these immune complexes. In thisway, C1q acts to bridge the innate and adaptive immune systems.
Complement also has an important role in the induction of antibodyresponses.62 This was shown first by Pepys, who demonstratedthat the formation of antibodies against T-cell–dependentantigens was reduced in animals in which C3 had been depleted.63,64This result, which was . . . [Full Text of this Article]
Complement and Inflammation
Complement and Necrosis
Complement and Immune Complexes
Complement Deficiency and Systemic Lupus Erythematosus
The "Waste-Disposal" Hypothesis
Conclusions
Source Information
From the Rheumatology Section, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London.
Address reprint requests to Dr. Walport at the Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Rd., London W12 0NN, United Kingdom, or at m.walport@ic.ac.uk.
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