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Editorial
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Volume 344:1242-1244 April 19, 2001 Number 16
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Can Estrogen or Selective Estrogen-Receptor Modulators Preserve Cognitive Function in Elderly Women?

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The use of estrogen-replacement therapy has been associated with a lower risk of Alzheimer's disease1 and preserved or enhanced cognitive performance in postmenopausal women.2 Despite the consistency of these observations, there are lingering doubts surrounding the observational studies of estrogen use. The failure to measure factors such as differences in the health-seeking behavior or socioeconomic status of women who choose to use or not to use estrogen has been an important limitation. It has therefore become important to conduct well-designed, controlled clinical trials of estrogen-replacement therapy for the treatment or prevention of cognitive impairment and dementia. More recently, selective estrogen-receptor . . . [Full Text of this Article]

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