At least 225,000 people in the United States will die suddenlythis year from coronary heart disease before they reach a hospital.1,2In addition, an estimated 370,000 to 750,000 patients will havea cardiac arrest and undergo attempted resuscitation duringhospitalization.3 The causes of cardiac arrest are numerous;by far the most common in adults is ischemic cardiovasculardisease.4,5,6 The arrest is usually associated with the lethalarrhythmia of ventricular fibrillation triggered by an acutelyischemic or infarcted myocardium or by a primary electricaldisturbance. The precipitants of a life-threatening arrhythmiasuch as ventricular fibrillation are poorly understood.6,7 Thedemographic . . . [Full Text of this Article]
The Chain of Survival
Rapid Access
Rapid Cardiopulmonary Resuscitation
Rapid Defibrillation
Rapid Advanced Care
Management of Cardiac Arrest
Ventricular Fibrillation and Pulseless Ventricular Tachycardia
Pulseless Electrical Activity
Asystole
Immediate Postresuscitation Care
Common Errors in Cardiac Resuscitation
Controversies and New Developments
When to Stop
When Not to Start
Source Information
From the Division of Emergency Medicine, Department of Medicine, University of Washington, Seattle.
Address reprint requests to Dr. Eisenberg at the Emergency Medicine Service, University of Washington Medical Center, Box 356123, Seattle, WA 98195-6123, or at gingy@u.washington.edu.
References
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Pascale, P., Schlaepfer, J., Oddo, M., Schaller, M.-D., Vogt, P., Fromer, M.
(2009). Ventricular arrhythmia in coronary artery disease: limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization. Europace
11: 1639-1646
[Abstract][Full Text]
Marcus, G. M., Keung, E., Scheinman, M. M.
(2009). The year in review of clinical cardiac electrophysiology.. J Am Coll Cardiol
54: 777-787
[Full Text]
Folke, F., Lippert, F. K., Nielsen, S. L., Gislason, G. H., Hansen, M. L., Schramm, T. K., Sorensen, R., Fosbol, E. L., Andersen, S. S., Rasmussen, S., Kober, L., Torp-Pedersen, C.
(2009). Location of Cardiac Arrest in a City Center: Strategic Placement of Automated External Defibrillators in Public Locations. Circulation
120: 510-517
[Abstract][Full Text]
Chan, P. S., Nichol, G., Krumholz, H. M., Spertus, J. A., Nallamothu, B. K., for the American Heart Association National Regist,
(2009). Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest. Arch Intern Med
169: 1265-1273
[Abstract][Full Text]
Sasson, C., Forman, J., Krass, D., Macy, M., Kellermann, A. L., McNally, B. F.
(2009). A Qualitative Study to Identify Barriers to Local Implementation of Prehospital Termination of Resuscitation Protocols. Circ Cardiovasc Qual Outcomes
2: 361-368
[Abstract][Full Text]
Pronovost, P. J., Goeschel, C. A., Olsen, K. L., Pham, J. C., Miller, M. R., Berenholtz, S. M., Sexton, J. B., Marsteller, J. A., Morlock, L. L., Wu, A. W., Loeb, J. M., Clancy, C. M.
(2009). Reducing Health Care Hazards: Lessons From The Commercial Aviation Safety Team. Health Aff (Millwood)
28: w479-w489
[Abstract][Full Text]
Dichtwald, S., Matot, I., Einav, S.
(2009). Improving the Outcome of In-Hospital Cardiac Arrest: The Importance of Being EARNEST. SEMIN CARDIOTHORAC VASC ANESTH
13: 19-30
[Abstract]
Sasson, C., Kellermann, A. L., McNally, B. F.
(2009). Termination of Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest. JAMA
301: 722-722
[Full Text]
Zed, P. J., Abu-Laban, R. B., Shuster, M., Green, R. S., Slavik, R. S., Travers, A. H.
(2008). Update on cardiopulmonary resuscitation and emergency cardiovascular care guidelines. Am J Health Syst Pharm
65: 2337-2346
[Abstract][Full Text]
Osorio, J., Dosdall, D. J., Robichaux, R. P. Jr, Tabereaux, P. B., Ideker, R. E.
(2008). In a Swine Model, Chest Compressions Cause Ventricular Capture and, By Means of a Long-Short Sequence, Ventricular Fibrillation. Circ Arrhythm Electrophysiol
1: 282-289
[Abstract][Full Text]
Edelson, D. P., Litzinger, B., Arora, V., Walsh, D., Kim, S., Lauderdale, D. S., Vanden Hoek, T. L., Becker, L. B., Abella, B. S.
(2008). Improving In-Hospital Cardiac Arrest Process and Outcomes With Performance Debriefing. Arch Intern Med
168: 1063-1069
[Abstract][Full Text]
Haissaguerre, M., Derval, N., Sacher, F., Jesel, L., Deisenhofer, I., de Roy, L., Pasquie, J.-L., Nogami, A., Babuty, D., Yli-Mayry, S., De Chillou, C., Scanu, P., Mabo, P., Matsuo, S., Probst, V., Le Scouarnec, S., Defaye, P., Schlaepfer, J., Rostock, T., Lacroix, D., Lamaison, D., Lavergne, T., Aizawa, Y., Englund, A., Anselme, F., O'Neill, M., Hocini, M., Lim, K. T., Knecht, S., Veenhuyzen, G. D., Bordachar, P., Chauvin, M., Jais, P., Coureau, G., Chene, G., Klein, G. J., Clementy, J.
(2008). Sudden Cardiac Arrest Associated with Early Repolarization. NEJM
358: 2016-2023
[Abstract][Full Text]
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Toff, W. D., Tonkin, A. M., Smith, W., Dorian, P., Packer, D. L., White, R. D., Longstreth, W.T. Jr., Anderson, J., Johnson, G., Bischoff, E., Yallop, J. J., McNulty, S., Ray, L. D., Clapp-Channing, N. E., Rosenberg, Y., Schron, E. B., the HAT Investigators,
(2008). Home Use of Automated External Defibrillators for Sudden Cardiac Arrest. NEJM
358: 1793-1804
[Abstract][Full Text]
Chan, P. S., Krumholz, H. M., Nichol, G., Nallamothu, B. K., the American Heart Association National Registry o,
(2008). Delayed Time to Defibrillation after In-Hospital Cardiac Arrest. NEJM
358: 9-17
[Abstract][Full Text]
Saxon, L. A.
(2008). Survival after Tachyarrhythmic Arrest -- What Are We Waiting For?. NEJM
358: 77-79
[Full Text]
Zhou, X., Fan, G.-C., Ren, X., Waggoner, J. R., Gregory, K. N., Chen, G., Jones, W. K., Kranias, E. G.
(2007). Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. Cardiovasc Res
75: 487-497
[Abstract][Full Text]
Cooper, J. A., Cooper, J. D., Cooper, J. M.
(2006). Cardiopulmonary Resuscitation: History, Current Practice, and Future Direction. Circulation
114: 2839-2849
[Full Text]
Adrie, C., Cariou, A., Mourvillier, B., Laurent, I., Dabbane, H., Hantala, F., Rhaoui, A., Thuong, M., Monchi, M.
(2006). Predicting survival with good neurological recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA score. Eur Heart J
27: 2840-2845
[Abstract][Full Text]
Jouven, X., Lemaitre, R. N., Rea, T. D., Sotoodehnia, N., Empana, J.-P., Siscovick, D. S.
(2005). Diabetes, glucose level, and risk of sudden cardiac death. Eur Heart J
26: 2142-2147
[Abstract][Full Text]
Koshman, S. L, Zed, P. J, Abu-Laban, R. B
(2005). Vasopressin in Cardiac Arrest. The Annals of Pharmacotherapy
39: 1687-1692
[Abstract][Full Text]
Adrie, C., Monchi, M., Laurent, I., Um, S., Yan, S. B., Thuong, M., Cariou, A., Charpentier, J., Dhainaut, J. F.
(2005). Coagulopathy After Successful Cardiopulmonary Resuscitation Following Cardiac Arrest: Implication of the Protein C Anticoagulant Pathway. J Am Coll Cardiol
46: 21-28
[Abstract][Full Text]
Mallet, R. T., Sun, J., Knott, E. M., Sharma, A. B., Olivencia-Yurvati, A. H.
(2005). Metabolic Cardioprotection by Pyruvate: Recent Progress. Exp. Biol. Med.
230: 435-443
[Abstract][Full Text]
Bunch, T. J., Hammill, S. C., White, R. D.
(2005). Outcomes After Ventricular Fibrillation Out-of-Hospital Cardiac Arrest: Expanding the Chain of Survival. Mayo Clin Proc.
80: 774-782
[Abstract]
Abella, B. S., Sandbo, N., Vassilatos, P., Alvarado, J. P., O'Hearn, N., Wigder, H. N., Hoffman, P., Tynus, K., Vanden Hoek, T. L., Becker, L. B.
(2005). Chest Compression Rates During Cardiopulmonary Resuscitation Are Suboptimal: A Prospective Study During In-Hospital Cardiac Arrest. Circulation
111: 428-434
[Abstract][Full Text]
Abella, B. S., Alvarado, J. P., Myklebust, H., Edelson, D. P., Barry, A., O'Hearn, N., Vanden Hoek, T. L., Becker, L. B.
(2005). Quality of Cardiopulmonary Resuscitation During In-Hospital Cardiac Arrest. JAMA
293: 305-310
[Abstract][Full Text]
Marco, C. A., Buderer, N., Thum, D. Sr.
(2005). End-of-life care: Perspectives of family members of deceased patients. AM J HOSP PALLIAT CARE
22: 26-31
[Abstract]
Herlitz, J, Engdahl, J, Svensson, L, Young, M, Angquist, K-A, Holmberg, S
(2004). Can we define patients with no chance of survival after out-of-hospital cardiac arrest?. Heart
90: 1114-1118
[Abstract][Full Text]
Zafari, A. M., Zarter, S. K., Heggen, V., Wilson, P., Taylor, R. A., Reddy, K., Backscheider, A. G., Dudley, S. C. Jr
(2004). A program encouraging early defibrillation results in improved in-hospital resuscitation efficacy. J Am Coll Cardiol
44: 846-852
[Abstract][Full Text]
Josephson, M., Wellens, H. J.J.
(2004). Implantable Defibrillators and Sudden Cardiac Death. Circulation
109: 2685-2691
[Full Text]
Goldhaber, S. Z., Nadel, E. S., King, M. E., Sharma, A.
(2004). Case 17-2004 - A 42-Year-Old Woman with Cardiac Arrest Several Weeks after an Ankle Fracture. NEJM
350: 2281-2290
[Full Text]
Bunch, T. J., White, R. D., Gersh, B. J., Shen, W.-K., Hammill, S. C., Packer, D. L.
(2004). Outcomes and In-hospital Treatment of Out-of-Hospital Cardiac Arrest Patients Resuscitated From Ventricular Fibrillation by Early Defibrillation. Mayo Clin Proc.
79: 613-619
[Abstract]
Booth, C. M., Boone, R. H., Tomlinson, G., Detsky, A. S.
(2004). Is This Patient Dead, Vegetative, or Severely Neurologically Impaired?: Assessing Outcome for Comatose Survivors of Cardiac Arrest. JAMA
291: 870-879
[Abstract][Full Text]
Wenzel, V., Krismer, A. C., Arntz, H. R., Sitter, H., Stadlbauer, K. H., Lindner, K. H., the European Resuscitation Council Vasopressor dur,
(2004). A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation. NEJM
350: 105-113
[Abstract][Full Text]
Rea, T. D., Crouthamel, M., Eisenberg, M. S., Becker, L. J., Lima, A. R.
(2003). Temporal Patterns in Long-Term Survival After Resuscitation From Out-of-Hospital Cardiac Arrest. Circulation
108: 1196-1201
[Abstract][Full Text]
Bunch, T. J., White, R. D., Gersh, B. J., Meverden, R. A., Hodge, D. O., Ballman, K. V., Hammill, S. C., Shen, W.-K., Packer, D. L.
(2003). Long-Term Outcomes of Out-of-Hospital Cardiac Arrest after Successful Early Defibrillation. NEJM
348: 2626-2633
[Abstract][Full Text]
Wellens, H. J.J., Gorgels, A. P., de Munter, H.
(2003). Cardiac Arrest Outside of a Hospital: How Can We Improve Results of Resuscitation?. Circulation
107: 1948-1950
[Full Text]
Herlitz, J, Eek, M, Holmberg, M, Engdahl, J, Holmberg, S
(2002). Characteristics and outcome among patients having out of hospital cardiac arrest at home compared with elsewhere. Heart
88: 579-582
[Abstract][Full Text]
Silfvast, T., Pettila, V., Ballew, K. A., Philbrick, J. T., Tomkiewicz, W., Meininghaus, D. G., Langes, K., Spehn, J., Dorian, P., Schwartz, B., Cooper, R.
(2002). Amiodarone versus Lidocaine for Shock-Resistant Ventricular Fibrillation. NEJM
347: 368-370
[Full Text]
Adrie, C., Adib-Conquy, M., Laurent, I., Monchi, M., Vinsonneau, C., Fitting, C., Fraisse, F., Dinh-Xuan, A. T., Carli, P., Spaulding, C., Dhainaut, J.-F., Cavaillon, J.-M.
(2002). Successful Cardiopulmonary Resuscitation After Cardiac Arrest as a "Sepsis-Like" Syndrome. Circulation
106: 562-568
[Abstract][Full Text]
Cheng, T. O., Maron, B. J., Estes III, N. A. M., Link, M. S.
(2002). Emergency Treatment for Commotio Cordis. JAMA
287: 3080-3080
[Full Text]
Abu-Laban, R. B., Christenson, J. M., Innes, G. D., van Beek, C. A., Wanger, K. P., McKnight, R. D., MacPhail, I. A., Puskaric, J., Sadowski, R. P., Singer, J., Schechter, M. T., Wood, V. M.
(2002). Tissue Plasminogen Activator in Cardiac Arrest with Pulseless Electrical Activity. NEJM
346: 1522-1528
[Abstract][Full Text]
Dorian, P., Cass, D., Schwartz, B., Cooper, R., Gelaznikas, R., Barr, A.
(2002). Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation. NEJM
346: 884-890
[Abstract][Full Text]
HOEPER, M. M., GALIE, N., MURALI, S., OLSCHEWSKI, H., RUBENFIRE, M., ROBBINS, I. M., FARBER, H. W., MCLAUGHLIN, V., SHAPIRO, S., PEPKE-ZABA, J., WINKLER, J., EWERT, R., OPITZ, C., WESTERKAMP, V., VACHIERY, J.-L., TORBICKI, A., BEHR, J., BARST, R. J.
(2002). Outcome after Cardiopulmonary Resuscitation in Patients with Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med.
165: 341-344
[Abstract][Full Text]
Zipes, D. P.
(2001). Saving Time Saves Lives. Circulation
104: 2506-2508
[Full Text]
Safar, P., Fine, R. H., von Baeyer, H., Eisenberg, M. S., Mengert, T. J.
(2001). Cardiac Resuscitation. NEJM
345: 546-547
[Full Text]