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Previous Volume 344:137-138 January 11, 2001 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Childs et al. (Sept. 14 issue)¹ report the spectacular success of nonmyeloablative allogeneic stem-cell transplantation in a subgroup of patients with metastatic renal-cell carcinoma. Only the patients with clear-cell carcinomas had responses. Previous work indicates that most renal-cell carcinomas with clear-cell histology are caused by mutation of the von Hippel–Lindau tumor-suppressor gene, located on chromosome band 3p26.^2,3 The von Hippel–Lindau gene produces two proteins that can suppress tumor formation in clear-cell renal-cell carcinoma in a nude-mouse model.⁴ My colleagues and I have demonstrated that the von Hippel–Lindau gene, in addition to its tumor-suppressor function, protects cells from . . . [Full Text of this Article]

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