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Previous Volume 344:1511-1514 May 17, 2001 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Hentz, V. R. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

For several decades, various approaches have been used to replace bone lost to trauma and disease. In 1908, Lexer¹ described attempts to reconstruct joints with newly amputated or cadaveric allografts. In more recent years, autografts² and allografts^3,4 have been used extensively to replace bone. Several natural or synthetic bone substitutes have also been used alone^5,6,7,8,9 or in conjunction with demineralized bone¹⁰ or autologous bone as vascularized or free (nonvascularized) grafts.^11,12 There have been numerous reports on the use of polypeptides^13,14 or demineralized bone powder^14,15 to stimulate the differentiation of mesenchymal tissue into bone.

More recently, living cells have been implanted . . . [Full Text of this Article]

Case Report

Methods

Procurement and in Vitro Culture of Autologous Cells

Implantation of the Cell–Scaffold Complex

Documentation of the Development of Bony Tissue

Results

Discussion

Source Information

From the Center for Tissue Engineering (C.A.V., L.J.B., M.P.V.); the Departments of Anesthesiology (C.A.V., L.J.B., M.P.V.), Cell Biology (L.J.B.), and Pathology (M.P.V.); and the Division of Plastic Surgery (J.S.) — all at the University of Massachusetts Medical School, Worcester.

Address reprint requests to Dr. Charles A. Vacanti at the Center for Tissue Engineering, University of Massachusetts Medical School, 55 Lake Ave. N., Worcester, MA 01655.

References

This article has been cited by other articles:

• Bajada, S., Harrison, P. E., Ashton, B. A., Cassar-Pullicino, V. N., Ashammakhi, N., Richardson, J. B. (2007). Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br 89-B: 1382-1386 [Abstract] [Full Text]  
• Hannouche, D., Raould, A., Nizard, R.S., Sedel, L., Petite, H. (2007). Embedding of Bone Samples in Methylmethacrylate: A Suitable Method for Tracking LacZ Mesenchymal Stem Cells in Skeletal Tissues. J. Histochem. Cytochem. 55: 255-262 [Abstract] [Full Text]  
• POLAK, J. M., BISHOP, A. E. (2006). Stem Cells and Tissue Engineering: Past, Present, and Future. Ann. N. Y. Acad. Sci. 1068: 352-366 [Abstract] [Full Text]  
• Kobayashi, T., Watanabe, H., Yanagawa, T., Tsutsumi, S., Kayakabe, M., Shinozaki, T., Higuchi, H., Takagishi, K. (2005). Motility and growth of human bone-marrow mesenchymal stem cells during ex vivo expansion in autologous serum. J Bone Joint Surg Br 87-B: 1426-1433 [Abstract] [Full Text]  
• Duailibi, M.T., Duailibi, S.E., Young, C.S., Bartlett, J.D., Vacanti, J.P., Yelick, P.C. (2004). Bioengineered Teeth from Cultured Rat Tooth Bud Cells. J. Dent. Res. 83: 523-528 [Abstract] [Full Text]  
• GODBEY, W. T., ATALA, A. (2002). In Vitro Systems for Tissue Engineering. Ann. N. Y. Acad. Sci. 961: 10-26 [Abstract] [Full Text]  
• Hentz, V. R., Chang, J. (2001). Tissue Engineering for Reconstruction of the Thumb. NEJM 344: 1547-1548 [Full Text]