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A 29-year-old man from northern Thailand had a three-week history of recurrent fever (a temperature of up to 40°C), generalized weakness, poor appetite, and weight loss. One week before hospitalization, papular skin lesions developed on his face (Panel A), chest, and arms, which enlarged and became umbilicated. He was found to be positive for the human immunodeficiency virus on enzyme-linked immunoassay but had not previously had an acquired immunodeficiency syndrome–defining illness. He was treated for a disseminated Penicillium marneffei infection with intravenous amphotericin B for two weeks, and the fever and skin lesions resolved. Therapy with oral itraconazole was then . . . [Full Text of this Article] |
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