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Previous Volume 344:1801-1802 June 7, 2001 Number 23 Next

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By Jon Cohen. 440 pp. New York, W.W. Norton, 2001. $27.95. ISBN 0-393-05027-0.

In 1984 — 17 years ago — Health and Human Services secretary Margaret Heckler announced that an AIDS vaccine would be ready for testing in 2 years. Since then, nearly 60 million persons worldwide have been infected by the human immunodeficiency virus (HIV), and only one vaccine, containing the gp120 surface protein of the virus, has made it to a large-scale, phase 3 efficacy field trial. Jon Cohen's book Shots in the Dark explains the reasons for this intolerably slow progress, despite the great advances that have been made in biotechnology, genetics, and immunology.

Cohen believes that a major obstacle . . . [Full Text of this Article]

This article has been cited by other articles:

• Steinbrook, R., Drazen, J. M. (2001). AIDS -- Will the Next 20 Years Be Different?. NEJM 344: 1781-1782 [Full Text]