To the Editor: Despite promising outcomes in the transplantationinto pediatric recipients of umbilical-cord blood from unrelateddonors, the low cell dose adversely affects both the rate ofhematopoietic recovery and the probability of survival.1,2,3The cell dose is a major limitation of the procedure, particularlyin adults. An alternative to the ex vivo expansion of cells,which has yet to be shown to be efficacious, is the transplantationof 2 closely HLA-matched units of umbilical-cord blood.
We transplanted 2 units of umbilical-cord blood from male infantdonors into a 53-year-old, 84-kg woman with accelerated-phasechronic myelogenous leukemia and no . . . [Full Text of this Article]
References
This article has been cited by other articles:
Placzek, M. R, Chung, I-M., Macedo, H. M, Ismail, S., Mortera Blanco, T., Lim, M., Min Cha, J., Fauzi, I., Kang, Y., Yeo, D. C.L, Yip Joan Ma, C., Polak, J. M, Panoskaltsis, N., Mantalaris, A.
(2009). Stem cell bioprocessing: fundamentals and principles. J R Soc Interface
6: 209-232
[Abstract][Full Text]
Komanduri, K. V., St. John, L. S., de Lima, M., McMannis, J., Rosinski, S., McNiece, I., Bryan, S. G., Kaur, I., Martin, S., Wieder, E. D., Worth, L., Cooper, L. J. N., Petropoulos, D., Molldrem, J. J., Champlin, R. E., Shpall, E. J.
(2007). Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood
110: 4543-4551
[Abstract][Full Text]