Respiratory Syncytial Virus and Parainfluenza Virus

doi:10.1056/NEJM200106213442507

Volume 344:1917-1928		June 21, 2001		Number 25

Respiratory Syncytial Virus and Parainfluenza Virus

Caroline Breese Hall, M.D.

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Respiratory syncytial virus (RSV), originally recovered froma colony of chimpanzees with coryza and designated chimpanzeecoryza agent,¹^,² and human parainfluenza virus types 1, 2, 3,and 4 have been known primarily as respiratory pathogens inyoung children. They are now recognized as important pathogensin adults as well. Adults infected with these viruses tend tohave more variable and less distinctive clinical findings thanchildren, and the viral cause of the infection is often unsuspected.The consistency of the annual outbreaks of these agents andthe frequency of reinfection suggest that they impose a considerable,but ill-defined, disease burden . . . [Full Text of this Article]

Classification and Structure

Epidemiologic Features

Pathogenesis

Effect of Disease in Children and Adults

Infections in Immunocompromised Patients

Reinfections in Previously Healthy Persons

Immunity

Diagnosis

Prospects for Immunization

Prophylaxis with Immune Globulin

Therapy

Conclusions

Source Information

From the University of Rochester School of Medicine and Dentistry, Rochester, N.Y.

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