FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 344:1979-1984 June 28, 2001 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and is now the third leading cause of end-stage renal disease in blacks 20 to 64 years of age.^1,2 These patients typically have proteinuria followed by a reduction in the glomerular filtration rate that progresses to end-stage renal disease in a few weeks or months. HIV-1–associated nephropathy is characterized morphologically by focal segmental glomerulosclerosis, tubular microcysts, interstitial fibrosis, and inflammation.^2,3,4,5

The pathogenesis of HIV-1–associated nephropathy is poorly understood, but increasing evidence suggests it is due to HIV-1 infection of renal . . . [Full Text of this Article]

Case Report

Methods

In Situ Hybridization

Immunohistochemical Analysis

PCR for Circular Forms of Viral DNA

Results

Discussion

Source Information

From the Divisions of Nephrology (J.A.W., L.A.B., M.D.R., L.R., P.E.K.) and Infectious Diseases (J.J., M.E.K.), Mt. Sinai School of Medicine; and the Department of Pathology, Columbia Presbyterian Medical Center (V.D.D.) — both in New York.

Address reprint requests to Dr. Mary E. Klotman at Box 1090, Mt. Sinai School of Medicine, 1 Gustave L. Levy Pl., New York, NY 10029, or at mary.klotman@mssm.edu.

References

This article has been cited by other articles:

• Hammer, S. M., Eron, J. J. Jr, Reiss, P., Schooley, R. T., Thompson, M. A., Walmsley, S., Cahn, P., Fischl, M. A., Gatell, J. M., Hirsch, M. S., Jacobsen, D. M., Montaner, J. S. G., Richman, D. D., Yeni, P. G., Volberding, P. A. (2008). Antiretroviral Treatment of Adult HIV Infection: 2008 Recommendations of the International AIDS Society-USA Panel. JAMA 300: 555-570 [Abstract] [Full Text]  
• Lu, T.-c., He, J. C., Wang, Z.-h., Feng, X., Fukumi-Tominaga, T., Chen, N., Xu, J., Iyengar, R., Klotman, P. E. (2008). HIV-1 Nef Disrupts the Podocyte Actin Cytoskeleton by Interacting with Diaphanous Interacting Protein. J. Biol. Chem. 283: 8173-8182 [Abstract] [Full Text]  
• Choi, A. I., Rodriguez, R. A., Bacchetti, P., Bertenthal, D., Volberding, P. A., O'Hare, A. M. (2007). Racial Differences in End-Stage Renal Disease Rates in HIV Infection versus Diabetes. J. Am. Soc. Nephrol. 18: 2968-2974 [Abstract] [Full Text]  
• Alpers, C. E., Kowalewska, J. (2007). Emerging Paradigms in the Renal Pathology of Viral Diseases. CJASN 2: S6-S12 [Abstract] [Full Text]  
• Wyatt, C. M., Klotman, P. E. (2007). HIV-1 and HIV-Associated Nephropathy 25 Years Later. CJASN 2: S20-S24 [Abstract] [Full Text]  
• Hatsukari, I., Singh, P., Hitosugi, N., Messmer, D., Valderrama, E., Teichberg, S., Chaung, W., Gross, E., Schmidtmayerova, H., Singhal, P. C. (2007). DEC-205-Mediated Internalization of HIV-1 Results in the Establishment of Silent Infection in Renal Tubular Cells. J. Am. Soc. Nephrol. 18: 780-787 [Abstract] [Full Text]  
• Atta, M. G., Gallant, J. E., Rahman, M. H., Nagajothi, N., Racusen, L. C., Scheel, P. J., Fine, D. M. (2006). Antiretroviral therapy in the treatment of HIV-associated nephropathy. Nephrol Dial Transplant 21: 2809-2813 [Abstract] [Full Text]  
• Zuo, Y., Matsusaka, T., Zhong, J., Ma, J., Ma, L.-j., Hanna, Z., Jolicoeur, P., Fogo, A. B., Ichikawa, I. (2006). HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis. J. Am. Soc. Nephrol. 17: 2832-2843 [Abstract] [Full Text]  
• Pawar, R. D., Patole, P. S., Wornle, M., Anders, H.-J. (2006). Microbial nucleic acids pay a Toll in kidney disease. Am. J. Physiol. Renal Physiol. 291: F509-F516 [Abstract] [Full Text]  
• Ross, M. J., Wosnitzer, M. S., Ross, M. D., Granelli, B., Gusella, G. L., Husain, M., Kaufman, L., Vasievich, M., D'Agati, V. D., Wilson, P. D., Klotman, M. E., Klotman, P. E. (2006). Role of Ubiquitin-Like Protein FAT10 in Epithelial Apoptosis in Renal Disease. J. Am. Soc. Nephrol. 17: 996-1004 [Abstract] [Full Text]  
• Audige, A., Schlaepfer, E., Joller, H., Speck, R. F. (2005). Uncoupled Anti-HIV and Immune-Enhancing Effects when Combining IFN-{alpha} and IL-7. J. Immunol. 175: 3724-3736 [Abstract] [Full Text]  
• Izzedine, H., Wirden, M., Launay-Vacher, V. (2005). Viral Load and HIV-Associated Nephropathy. NEJM 353: 1072-1074 [Full Text]  
• Schwartz, E. J., Szczech, L. A., Ross, M. J., Klotman, M. E., Winston, J. A., Klotman, P. E. (2005). Highly Active Antiretroviral Therapy and the Epidemic of HIV+ End-Stage Renal Disease. J. Am. Soc. Nephrol. 16: 2412-2420 [Abstract] [Full Text]  
• Eggers, P. W., Kimmel, P. L. (2004). Is There an Epidemic of HIV Infection in the US ESRD Program?. J. Am. Soc. Nephrol. 15: 2477-2485 [Abstract] [Full Text]  
• Gharavi, A. G., Ahmad, T., Wong, R. D., Hooshyar, R., Vaughn, J., Oller, S., Frankel, R. Z., Bruggeman, L. A., D'Agati, V. D., Klotman, P. E., Lifton, R. P. (2004). Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc. Natl. Acad. Sci. USA 101: 2488-2493 [Abstract] [Full Text]  
• Olatinwo, T., Hewitt, R. G., Venuto, R. C. (2004). Human Immunodeficiency Virus-Associated Nephropathy: A Primary Care Perspective. Arch Intern Med 164: 333-336 [Abstract] [Full Text]  
• Kimmel, P. L., Barisoni, L., Kopp, J. B. (2003). Pathogenesis and Treatment of HIV-Associated Renal Diseases: Lessons from Clinical and Animal Studies, Molecular Pathologic Correlations, and Genetic Investigations. ANN INTERN MED 139: 214-226 [Abstract] [Full Text]  
• Nelson, P. J., D'Agati, V. D., Gries, J.-M., Suarez, J.-R., Gelman, I. H. (2003). Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol. J Antimicrob Chemother 51: 921-929 [Abstract] [Full Text]  
• Ross, M. J., Klotman, P. E. (2002). Recent Progress in HIV-Associated Nephropathy. J. Am. Soc. Nephrol. 13: 2997-3004 [Full Text]  
• Betjes, M. G. H., Verhagen, D. W. M. (2002). Stable improvement of renal function after initiation of highly active anti-retroviral therapy in patients with HIV-1-associated nephropathy. Nephrol Dial Transplant 17: 1836-1839 [Full Text]  
• Conaldi, P. G., Bottelli, A., Baj, A., Serra, C., Fiore, L., Federico, G., Bussolati, B., Camussi, G. (2002). Human Immunodeficiency Virus-1 Tat Induces Hyperproliferation and Dysregulation of Renal Glomerular Epithelial Cells. Am. J. Pathol. 161: 53-61 [Abstract] [Full Text]  
• (2001). The Kidney Shelters HIV. AIDS Clin Care 2001: 1-1 [Full Text]