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Previous Volume 344:1979-1984 June 28, 2001 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and is now the third leading cause of end-stage renal disease in blacks 20 to 64 years of age.^1,2 These patients typically have proteinuria followed by a reduction in the glomerular filtration rate that progresses to end-stage renal disease in a few weeks or months. HIV-1–associated nephropathy is characterized morphologically by focal segmental glomerulosclerosis, tubular microcysts, interstitial fibrosis, and inflammation.^2,3,4,5

The pathogenesis of HIV-1–associated nephropathy is poorly understood, but increasing evidence suggests it is due to HIV-1 infection of renal . . . [Full Text of this Article]

Case Report

Methods

In Situ Hybridization

Immunohistochemical Analysis

PCR for Circular Forms of Viral DNA

Results

Discussion

Source Information

From the Divisions of Nephrology (J.A.W., L.A.B., M.D.R., L.R., P.E.K.) and Infectious Diseases (J.J., M.E.K.), Mt. Sinai School of Medicine; and the Department of Pathology, Columbia Presbyterian Medical Center (V.D.D.) — both in New York.

Address reprint requests to Dr. Mary E. Klotman at Box 1090, Mt. Sinai School of Medicine, 1 Gustave L. Levy Pl., New York, NY 10029, or at mary.klotman@mssm.edu.

References

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