The chief reason that patients are admitted to an intensivecare unit is to receive ventilatory support. In this article,I update the basic principles of mechanical ventilation, whichI reviewed in the Journal in 1994,1 and discuss recent advances.
Basic Principles
The indications for mechanical ventilation, as derived froma study of 1638 patients in eight countries,2 are acute respiratoryfailure (66 percent of patients), coma (15 percent), acute exacerbationof chronic obstructive pulmonary disease (13 percent), and neuromusculardisorders (5 percent). The disorders in the first group includethe acute respiratory distress syndrome, heart failure, pneumonia,sepsis, complications of surgery, . . . [Full Text of this Article]
Coordinating Respiratory Effort and Mechanical Ventilation
Improving Oxygenation and Preventing Lung Injury
Discontinuing Mechanical Ventilation
Other Approaches to Mechanical Ventilation
Conclusions
Source Information
From the Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr., Veterans Affairs Hospital and Loyola University of Chicago Stritch School of Medicine, Hines, Ill.
Address reprint requests to Dr. Tobin at the Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr., Veterans Affairs Hospital, Rte. 111N, Hines, IL 60141, or at mtobin2@luc.edu.
References
This article has been cited by other articles:
Lytle, F. T., Brown, D. R.
(2008). Appropriate Ventilatory Settings for Thoracic Surgery: Intraoperative and Postoperative. SEMIN CARDIOTHORAC VASC ANESTH
12: 97-108
[Abstract]
Meade, M. O., Cook, D. J., Guyatt, G. H., Slutsky, A. S., Arabi, Y. M., Cooper, D. J., Davies, A. R., Hand, L. E., Zhou, Q., Thabane, L., Austin, P., Lapinsky, S., Baxter, A., Russell, J., Skrobik, Y., Ronco, J. J., Stewart, T. E., for the Lung Open Ventilation Study Investigators,
(2008). Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA
299: 637-645
[Abstract][Full Text]
Malhotra, A.
(2007). Low-Tidal-Volume Ventilation in the Acute Respiratory Distress Syndrome. NEJM
357: 1113-1120
[Full Text]
Hughes-Davies, T., Arah, O. A., Kahn, J. M., Rubenfeld, G. D.
(2006). Hospital volume and outcomes of mechanical ventilation.. NEJM
355: 1617-1617
[Full Text]
Crimi, E., Zhang, H., Han, R. N. N., Sorbo, L. D., Ranieri, V.M., Slutsky, A. S.
(2006). Ischemia and Reperfusion Increases Susceptibility to Ventilator-induced Lung Injury in Rats. Am. J. Respir. Crit. Care Med.
174: 178-186
[Abstract][Full Text]
Moerer, O., Fischer, S., Hartelt, M., Kuvaki, B., Quintel, M., Neumann, P.
(2006). Influence of Two Different Interfaces for Noninvasive Ventilation Compared to Invasive Ventilation on the Mechanical Properties and Performance of a Respiratory System: A Lung Model Study. Chest
129: 1424-1431
[Abstract][Full Text]
L'Her, E., Deye, N., Lellouche, F., Taille, S., Demoule, A., Fraticelli, A., Mancebo, J., Brochard, L.
(2005). Physiologic Effects of Noninvasive Ventilation during Acute Lung Injury. Am. J. Respir. Crit. Care Med.
172: 1112-1118
[Abstract][Full Text]
Doerr, C. H., Gajic, O., Berrios, J. C., Caples, S., Abdel, M., Lymp, J. F., Hubmayr, R. D.
(2005). Hypercapnic Acidosis Impairs Plasma Membrane Wound Resealing in Ventilator-injured Lungs. Am. J. Respir. Crit. Care Med.
171: 1371-1377
[Abstract][Full Text]
Jubran, A., Grant, B. J. B., Laghi, F., Parthasarathy, S., Tobin, M. J.
(2005). Weaning Prediction: Esophageal Pressure Monitoring Complements Readiness Testing. Am. J. Respir. Crit. Care Med.
171: 1252-1259
[Abstract][Full Text]
Eutamene, H., Theodorou, V., Schmidlin, F., Tondereau, V., Garcia-Villar, R., Salvador-Cartier, C., Chovet, M., Bertrand, C., Bueno, L.
(2005). LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK. Eur Respir J
25: 789-796
[Abstract][Full Text]
Burleson, B. S., Maki, E. D.
(2005). Acute Respiratory Distress Syndrome. Journal of Pharmacy Practice
18: 118-131
[Abstract]
Kornecki, A., Tsuchida, S., Ondiveeran, H. K., Engelberts, D., Frndova, H., Tanswell, A. K., Post, M., McKerlie, C., Belik, J., Fox-Robichaud, A., Kavanagh, B. P.
(2005). Lung Development and Susceptibility to Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med.
171: 743-752
[Abstract][Full Text]
Jackson, W L Jr, Gallagher, C, Myhand, R C, Waselenko, J K
(2005). Medical management of patients with multiple organ dysfunction arising from acute radiation syndrome. Br. J. Radiol.
Supplement_27: 161-168
[Abstract][Full Text]
Tobin, M. J.
(2004). Of Principles and Protocols and Weaning. Am. J. Respir. Crit. Care Med.
169: 661-662
[Full Text]
Prinianakis, G., Delmastro, M., Carlucci, A., Ceriana, P., Nava, S.
(2004). Effect of varying the pressurisation rate during noninvasive pressure support ventilation. Eur Respir J
23: 314-320
[Abstract][Full Text]
Magder, S.
(2004). Clinical Usefulness of Respiratory Variations in Arterial Pressure. Am. J. Respir. Crit. Care Med.
169: 151-155
[Full Text]
Allen, G., Bates, J. H. T.
(2004). Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury. J. Appl. Physiol.
96: 293-300
[Abstract][Full Text]
Sinderby, C.
(2003). Ventilatory Assist Driven by Patient Demand. Am. J. Respir. Crit. Care Med.
168: 729-730
[Full Text]
Terragni, P.P., Rosboch, G.L., Lisi, A., Viale, A.G., Ranieri, V.M.
(2003). How respiratory system mechanics may help in minimising ventilator-induced lung injury in ARDS patients. Eur Respir J
22: 15s-21s
[Abstract][Full Text]
de Chazal, I., Hubmayr, R. D.
(2003). Novel aspects of pulmonary mechanics in intensive care. Br J Anaesth
91: 81-91
[Full Text]
Wainwright, M. S., Rossi, J., Schavocky, J., Crawford, S., Steinhorn, D., Velentza, A. V., Zasadzki, M., Shirinsky, V., Jia, Y., Haiech, J., Van Eldik, L. J., Watterson, D. M.
(2003). Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc. Natl. Acad. Sci. USA
100: 6233-6238
[Abstract][Full Text]
Vitacca, M., Barbano, L., D'Anna, S., Porta, R., Bianchi, L., Ambrosino, N.
(2002). Comparison of Five Bilevel Pressure Ventilators in Patients With Chronic Ventilatory Failure: A Physiologic Study. Chest
122: 2105-2114
[Abstract][Full Text]
Parthasarathy, S., Tobin, M. J.
(2002). Effect of Ventilator Mode on Sleep Quality in Critically Ill Patients. Am. J. Respir. Crit. Care Med.
166: 1423-1429
[Abstract][Full Text]
Derdak, S., Mehta, S., Stewart, T. E., Smith, T., Rogers, M., Buchman, T. G., Carlin, B., Lowson, S., Granton, J., the Multicenter Oscillatory Ventilation,
(2002). High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults: A Randomized, Controlled Trial. Am. J. Respir. Crit. Care Med.
166: 801-808
[Abstract][Full Text]
Tung, A., Morgan, S. E.
(2002). Modeling the Effect of Progressive Endotracheal Tube Occlusion on Tidal Volume in Pressure-Control Mode. Anesth. Analg.
95: 192-197
[Abstract][Full Text]
Hubmayr, R. D.
(2002). Perspective on Lung Injury and Recruitment: A Skeptical Look at the Opening and Collapse Story. Am. J. Respir. Crit. Care Med.
165: 1647-1653
[Full Text]
Ambrosino, N, Rossi, A
(2002). Proportional assist ventilation (PAV): a significant advance or a futile struggle between logic and practice?. Thorax
57: 272-276
[Abstract][Full Text]
Martinon-Torres, F., Rodriguez-Nunez, A., Martinon-Sanchez, J. M., Tobin, M. J.
(2001). Advances in Mechanical Ventilation. NEJM
345: 1133-1134
[Full Text]