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Editorial
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Volume 344:222-223 January 18, 2001 Number 3
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Discontinuing Pneumocystis carinii Prophylaxis

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 by de Quiros, J. C. L. B.
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 by Ledergerber, B.
-PubMed Citation
Until the widespread adoption of specific prophylaxis in the late 1980s, Pneumocystis carinii pneumonia was among the most common life-threatening opportunistic infections associated with infection with the human immunodeficiency virus (HIV) in industrialized countries. Primary prophylaxis against P. carinii pneumonia is currently recommended for all HIV-infected patients with CD4 cell counts of less than 200 per cubic millimeter and for those receiving cytotoxic chemotherapy. Secondary prophylaxis is recommended for all patients with a history of P. carinii pneumonia.1

The advent of highly active antiretroviral therapy, which can drastically inhibit HIV replication and lead to substantial increases in CD4 cell counts, . . . [Full Text of this Article]

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