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Previous Volume 344:276-285 January 25, 2001 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The connection between breast cancer and estrogen has been recognized for more than 100 years, since George Beatson demonstrated that bilateral oophorectomy resulted in the remission of breast cancer in premenopausal women.¹ Subsequent evidence has implicated both endogenous and exogenous estrogen in the pathogenesis of breast cancer. In this article, we review the relation between estrogen and the risk of breast cancer.

Estrogen and Breast Carcinogenesis

Experimental data strongly suggest that estrogens have a role in the development and growth of breast cancer.² Although the exact mechanisms remain to be fully elucidated, the alkylation of cellular molecules and the generation of active radicals that . . . [Full Text of this Article]

Estrogen Synthesis

Sensitivity of Tissue to Estrogens

Catabolism of Estrogens

Clinical Markers of Exposure to Estrogen and the Risk of Breast Cancer

Serum Estrogen Concentrations

Breast Density

Bone Density

Conclusions

Source Information

From the Department of Medical Oncology, Princess Margaret Hospital, University Health Network, Toronto.

Address reprint requests to Dr. Goss at the Department of Medical Oncology, Princess Margaret Hospital, 5-303, 610 University Ave., Toronto, ON M5G 2M9, Canada, or at pegoss@interlog.com.

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