The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Correspondence
PreviousPrevious
Volume 344:307 January 25, 2001 Number 4
NextNext

Shortened Zidovudine Regimens to Prevent Mother-To-Child Transmission of HIV-1

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited

More Information
To the Editor: In their study of simplified and less costly regimens of zidovudine to reduce mother-to-child transmission of the human immunodeficiency virus (HIV), Lallemant et al. (Oct. 5 issue)1 used an intention-to-treat analysis of the efficacy of the interventions. Intention-to-treat analyses are widely regarded as "conservative" because they tend to minimize differences among treatment groups and thus bias the results toward the conventional null effect of no difference between groups. However, because equivalency studies essentially flip the conventional null and alternative hypotheses, such a bias may produce a "false positive" outcome of equivalence when, in fact, one treatment is . . . [Full Text of this Article]

References



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.