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In the early 1980s, clinicians in urban centers became increasingly alarmed as young homosexual and bisexual men presented with a life-threatening disease that seemed related to a severe immunodeficiency. The Morbidity and Mortality Weekly Report announced cases of the disease among gay men in 1981. Reports of diseases and cancers never seen in healthy young people, including Pneumocystis carinii pneumonia, Kaposi's sarcoma, cryptococcal meningitis, and toxoplasma encephalitis, slowly entered medical publications throughout the United States.
In New York, San Francisco, and Miami, physicians initially noted that their patients were exclusively men who had sex with men, injection-drug users, and hemophiliacs.
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