Asthma is a complex syndrome with many clinical phenotypes inboth adults and children. Its major characteristics includea variable degree of airflow obstruction, bronchial hyperresponsiveness,and airway inflammation. For many patients, the disease hasits roots in infancy, and both genetic factors (atopy)1,2 andenvironmental factors (viruses,3 allergens,4 and occupationalexposures5) contribute to its inception and evolution. To comprehendthe pathogenetic mechanisms underlying the many variants ofasthma, it is essential to identify factors that initiate, intensify,and modulate the inflammatory response of the airway and todetermine how these immunologic and biologic processes producethe characteristic airway . . . [Full Text of this Article]
Immunohistopathology of Asthma
Allergic Inflammation in Asthma
Mast Cells
Eosinophils
Lymphocytes
An Imbalance between Th1 and Th2 Cells and the Origins of Asthma
Airway Remodeling in Asthma
Therapy
Conclusions
Source Information
From the Departments of Medicine (W.W.B.) and Pediatrics (R.F.L.), University of Wisconsin, Madison.
Address reprint requests to Dr. Busse at the University of Wisconsin Hospital, K4/910 CSC–9988, 600 Highland Ave., Madison, WI 53792, or at wwb@medicine.wisc.edu.
References
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