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Previous Volume 344:385-386 February 1, 2001 Number 5 Next

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To the Editor: The reconstruction of large bone segments is an important clinical problem, and none of the approaches proposed thus far have proved very effective. In animals, repair and functional recovery of segmental bone defects have been reported with the use of marrow-derived osteoprogenitor cells grown on scaffolds of macroporous hydroxyapatite.^1,2,3

We report the use of this cell-based tissue-engineering approach to treat three patients with large bone defects. Patient 1 was a 41-year-old woman with loss of a 4.0-cm segment of the mid-diaphysis of the right tibia as the result of an unsuccessful attempt at bone lengthening. Patient 2 . . . [Full Text of this Article]

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