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Correspondence
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Volume 344:386-387 February 1, 2001 Number 5
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Transmission of Glomerular Permeability Factor from a Mother to Her Child

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To the Editor: In the idiopathic nephrotic syndrome, including focal segmental glomerulosclerosis, a glomerular permeability factor may be responsible for the development of proteinuria and the recurrence of disease after renal transplantation.1,2 Plasma from patients with active focal segmental glomerulosclerosis can cause proteinuria in rats.3 The effect of a glomerular permeability factor after transmission from one person to another is not known. We report the transfer of an unknown glomerular permeability factor from a mother with focal segmental glomerulosclerosis to her child.

The nephrotic syndrome developed in a 35-year-old woman (gravida 5, para 3) in the 13th week of gestation . . . [Full Text of this Article]

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