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Previous Volume 344:458 February 8, 2001 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their article, Lipshultz and colleagues (Sept. 14 issue)¹ conclude that perinatal exposure to zidovudine does not result in echocardiographic evidence of acute or chronic cardiac abnormalities. The importance of perinatal treatment with antiretroviral agents in pregnant women who are infected with human immunodeficiency virus type 1 (HIV-1) is clear. Despite the importance of this study, the long-term effects of zidovudine on the heart in children and adults may require further exploration.

My group and others demonstrated that high-dose zidovudine caused mitochondrial cardiomyopathy in rats² and worsened cardiac dysfunction in adult transgenic mice with AIDS.³ This resulted . . . [Full Text of this Article]

References

This article has been cited by other articles:

• White, A. J (2001). Mitochondrial toxicity and HIV therapy. Sex. Transm. Infect. 77: 158-173 [Abstract] [Full Text]