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Previous Volume 344:528-530 February 15, 2001 Number 7 Next

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To the Editor: Hayden et al. (Nov. 2 issue)¹ identified an index case with an influenza-like illness in 337 families, and assigned the family contacts to prophylaxis with either zanamivir or placebo. Among the 414 family contacts who received zanamivir, influenza developed in 7 (1.7 percent), as compared with 40 of the 423 contacts who received placebo (9.5 percent). Prophylaxis reduced the transmission of influenza by about 80 percent. But there are some problems. Although subjects with index cases of influenza-like symptoms were selected, only 165 of the 337 (49 percent) actually had influenza. Hence, as the accompanying editorial notes, . . . [Full Text of this Article]

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