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Previous Volume 344:686-688 March 1, 2001 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Esteller and colleagues (Nov. 9 issue)¹ claim that methylation of the O⁶-methylguanine-DNA methyltransferase (MGMT ) promoter is associated with improved responsiveness to carmustine and prolonged survival in patients with high-grade gliomas. We believe there are methodologic flaws in the authors' study that call these results into question. First, the patients in the study were treated with a combination of surgery, radiation therapy, and chemotherapy with cisplatin and carmustine. We do not believe the response to carmustine is a discernible end point in this trial, because multiple treatments were administered along with carmustine.

Second, although the . . . [Full Text of this Article]

References

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• Hegi, M. E., Diserens, A.-C., Godard, S., Dietrich, P.-Y., Regli, L., Ostermann, S., Otten, P., Van Melle, G., de Tribolet, N., Stupp, R. (2004). Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide. Clin. Cancer Res. 10: 1871-1874 [Abstract] [Full Text]  
• Balana, C., Ramirez, J. L., Taron, M., Roussos, Y., Ariza, A., Ballester, R., Sarries, C., Mendez, P., Sanchez, J. J., Rosell, R. (2003). O6-methyl-guanine-DNA methyltransferase Methylation in Serum and Tumor DNA Predicts Response to 1,3-Bis(2-Chloroethyl)-1-Nitrosourea but not to Temozolamide Plus Cisplatin in Glioblastoma Multiforme. Clin. Cancer Res. 9: 1461-1468 [Abstract] [Full Text]