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Previous Volume 344:692 March 1, 2001 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the second part of their review of the HLA system (Sept. 14 issue),¹ Klein and Sato state that the HLA class II association in human narcolepsy is due to linkage disequilibrium with mutations in the gene coding for the hypocretin type 2 receptor (HCRTR2). HCRTR2 is located on human chromosome 6, but at a very large genetic distance from the HLA loci; there is no linkage disequilibrium between the HLA alleles and HCRTR2 over a distance of more than 30 million base pairs and 33.4 centimorgans. However, there is a different association between narcolepsy . . . [Full Text of this Article]

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