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Previous Volume 345:41-52 July 5, 2001 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide and thus represents a viral pandemic, one that is five times as widespread as infection with the human immunodeficiency virus type 1 (HIV-1). The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure. Progression to chronic disease occurs in the majority of HCV-infected persons, and infection with the virus has become the main indication . . . [Full Text of this Article]

Epidemiologic Characteristics

Pathogenesis

Clinical Characteristics and the Natural Course of Disease

Diagnostic Tests

Treatment

Acute Infection

Chronic Infection

Initial Treatment Regimens

Pegylated Interferons

Treatment of Patients with Contraindications or Adverse Reactions to Ribavirin

Combination Treatment in Patients Who Relapse after the Cessation of Monotherapy with Interferon Alfa

Treatment of Patients with No Response to Monotherapy or Combination Therapy

Liver Transplantation

Treatment of Patients Coinfected with HIV-1

Conclusions and Future Directions

Source Information

From the Infectious Disease Division and Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston.

Address reprint requests to Dr. Walker at the Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital East, 149 13th St., Charlestown, MA 02129, or at bwalker@helix.mgh.harvard.edu.

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