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Previous Volume 345:57-59 July 5, 2001 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hemiplegic migraine (with or without cerebellar signs), spinocerebellar ataxia, and episodic ataxia can all result from changes in the gene that encodes the P/Q-type neuronal calcium channel, just one of the 35,000 or so genes that make up the human blueprint. The varied consequences of calcium-channel mutations have been a source of consternation for neuroscientists and geneticists. How can different mutations in the same gene result in both paroxysmal and progressive disorders? Why does the clinical expression of disease vary in patients within the same family with the same genetic change, and why is there so much clinical overlap among . . . [Full Text of this Article]

References

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• Schon, F, Martin, R J, Prevett, M, Clough, C, Enevoldson, T P, Markus, H S (2003). "CADASIL coma": an underdiagnosed acute encephalopathy. J. Neurol. Neurosurg. Psychiatry 74: 249-252 [Abstract] [Full Text]