Intravenous immune globulin has been used in the treatment ofprimary and secondary antibody deficiencies for more than 25years. It is a safe preparation with no long-term side effects.Intravenous immune globulin was first demonstrated to be effectivein an autoimmune disorder — idiopathic thrombocytopenicpurpura — two decades ago. Since then, it has been establishedto be efficacious in the treatment of the Guillain–Barrésyndrome, chronic inflammatory demyelinating polyneuropathy,myasthenia gravis, corticosteroid-resistant dermatomyositis,and Kawasaki's syndrome and in the prevention of graft-versus-hostdisease in recipients of allogeneic bone marrow transplants.Benefits have been reported in many other autoimmune . . . [Full Text of this Article]
Components of Intravenous Immune Globulin
Natural Antibodies
Antibodies against Soluble and Membrane Molecules Involved in Immune Regulation
Clinical Use of Intravenous Immune Globulin
Safety of Intravenous Immune Globulin
Mechanisms of Action of Immune Globulin
Fc Receptor–Mediated Effects
Antiinflammatory Effects
Effects on B Cells and Antibodies
Effects on T Cells
Conclusions
Source Information
From INSERM Unité 430, Hôpital Broussais and the Department of Clinical Immunology, Hôpital Européen Georges Pompidou and Université Pierre et Marie Curie — all in Paris.
Address reprint requests to Dr. Kazatchkine at INSERM U430, Hôpital Broussais, 96 rue Didot, 75014 Paris, France, or at michel.kazatchkine@egp.ap-hop-paris.fr.
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