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Original Article
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Volume 345:798-802 September 13, 2001 Number 11
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Wild-Mushroom Intoxication as a Cause of Rhabdomyolysis
Regis Bedry, M.D., Isabelle Baudrimont, Pharm.D., Ph.D., Gerard Deffieux, Pharm.D., Ph.D., Edmond E. Creppy, Pharm.D., Ph.D., Jean P. Pomies, M.D., Ph.D., Jean M. Ragnaud, M.D., Michel Dupon, M.D., Didier Neau, M.D., Claude Gabinski, M.D., Sten De Witte, M.D., Jean C. Chapalain, M.D., Jacques Beylot, M.D., and Pierre Godeau, M.D.

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The growing popularity of eating wild mushrooms has led to an increase in the incidence of mushroom poisoning. Most fatalities are due to amatoxin-containing species, which cause fulminant hepatocytolysis, and to cortinarius species, which lead to acute renal damage. A 1996 report described a patient with hepatic failure, encephalopathy, and myopathy related to the ingestion of Amanita phalloides.1 Since 1992, 12 cases of delayed rhabdomyolysis have occurred in France after meals that included large quantities of the edible wild mushroom Tricholoma equestre.2 The circumstances of these 12 cases clearly implicate T. equestre as the cause. The mushroom was . . . [Full Text of this Article]

Case Reports

Methods

Mushroom Extracts

Experimental Intoxication

Statistical Analysis

Results

Discussion


Source Information

From the Poison Center (R.B.) and the Department of Infectious Diseases (J.M.R., M.D., D.N.), University Hospital Pellegrin, Bordeaux; the Departments of Toxicology (I.B., E.E.C.) and Mycology (G.D.), Faculty of Pharmacy, University Bordeaux 2, Bordeaux; Histotox, La Rochelle (J.P.P.); the Departments of Intensive Care (C.G.) and Internal Medicine (S.D.), University Hospital St. André, Bordeaux; the Department of Gastroenterology, Hospital of Montbrisson, Montbrisson (J.C.C.); and the Department of Internal Medicine, University Hospital Pitié–Salpetrière, Paris (P.G.) — all in France.

Jacques Beylot, M.D., Department of Internal Medicine, University Hospital St. André, Bordeaux, France, was also an author.

Address reprint requests to Dr. Creppy at the Department of Toxicology, University Bordeaux 2, 146 rue Leo-Saignat, 33076 Bordeaux, France, or at edmond.creppy@tox.u-bordeaux2.fr.

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