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Correspondence
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Volume 345:841 September 13, 2001 Number 11
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Waterhouse–Friderichsen Syndrome

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To the Editor: The Waterhouse–Friderichsen syndrome was described by the British physician R.A. Waterhouse in 1911 as "a case of suprarenal apoplexy"1 and by C. Friderichsen, a Danish pediatrician, in 1918 as "Nebennierenapoplexie bei kleinen Kindern."2 Waterhouse's description of an unvaccinated eight-month-old boy with a purpuric rash who died within four hours after admission included postmortem findings of bilateral adrenal hemorrhage. No causative organism was found, and the assumption that the disease was related to the unvaccinated state of the infant may have been erroneous. Nevertheless, the description of the syndrome has evolved to include fulminant purpuric meningococcemia associated with . . . [Full Text of this Article]

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