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Previous Volume 345:924-925 September 20, 2001 Number 12 Next

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To the Editor: Gao et al. (May 31 issue)¹ report the identification of specific HLA-B*35-Px subtypes as responsible for the association between HLA-B*35 and rapid progression to AIDS, and they stress the importance of homozygosity for HLA-B*35 as a predictor of even more rapid progression. Their extensive analysis confirms the known protective effect of the HLA-B*27 and B*57 subtypes against progression to AIDS, at least in whites.²

Unlike Gao and colleagues, we think that there is an important influence of numerous major-histocompatibility-complex (MHC) gene products. The A1,B8,DR3 haplotype, for instance, has repeatedly been shown to be associated with fast progression . . . [Full Text of this Article]

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