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Previous Volume 345:926 September 20, 2001 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hereditary hemorrhagic telangiectasia is an autosomal dominant disease characterized by epistaxis, cutaneous telangiectases, and visceral arteriovenous malformations.¹ Aminocaproic acid, an antifibrinolytic drug, can reduce epistaxis in hereditary hemorrhagic telangiectasia,² but its effect is inconsistent.³ We successfully treated three patients who had hereditary hemorrhagic telangiectasia with tranexamic acid, another antifibrinolytic drug.

The first patient was a 69-year-old man who received 1 g of tranexamic acid four times daily. After three months of therapy, he reported an improvement in his epistaxis and his hemoglobin level rose from 10.3 g per deciliter to 12.3 g per deciliter. The second patient . . . [Full Text of this Article]

References

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• Shovlin, C L, Jackson, J E, Bamford, K B, Jenkins, I H, Benjamin, A R, Ramadan, H, Kulinskaya, E (2008). Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia. Thorax 63: 259-266 [Abstract] [Full Text]  
• Sabba, C., Pasculli, G., Suppressa, P., D'Ovidio, F., Lenato, G. M., Resta, F., Assennato, G., Guanti, G. (2006). Life expectancy in patients with hereditary haemorrhagic telangiectasia. QJM 99: 327-334 [Abstract] [Full Text]  
• Begbie, M E, Wallace, G M F, Shovlin, C L (2003). Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century. Postgrad. Med. J. 79: 18-24 [Abstract] [Full Text]  
• Lozano, M., Sabba, C., Gallitelli, M., Ciavarella, N. (2002). Tranexamic Acid in Hereditary Hemorrhagic Telangiectasia. NEJM 346: 457-457 [Full Text]