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Correspondence
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Volume 345:1000 September 27, 2001 Number 13
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Fatal Reactivation of Cytomegalovirus Infection after Use of Rituximab for a Post-Transplantation Lymphoproliferative Disorder

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To the Editor: Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen expressed on most B cells and is used to treat B-cell non-Hodgkin's lymphoma.1 Recently, rituximab has been used to treat post-transplantation lymphoproliferative disorders, which may occur after solid-organ and bone marrow transplantation; the prognosis associated with these disorders is usually poor, even if the doses of immunosuppressive drugs are reduced. Rituximab induces profound and durable B-cell depletion without a substantial decrease in serum immunoglobulin levels. Viral infection has rarely been reported after the use of this agent. Hepatitis B reactivation,1,2 visceral varicella–zoster infection,3 and pure red-cell . . . [Full Text of this Article]

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